Extravasation GuideTissue injury risk of antineoplastic extravasation

Bortezomib

Bortezomibe

Risk class

  • Nonvesicant

If it extravasates

Compress

  • Cold
References

Risk class: NonvesicantESMO-EONS 2012 (Table 1, p. vii167); JSCN/JSMO/JASPO 2024 (Table 2)

Compress: coldESMO-EONS 2012 (Fig. 1, p. vii170)

Not classified in: ONS/ASCO 2025

Details by guideline

Risk class in extravasation

Not classified in: ONS/ASCO 2025

Compress

  • ESMO-EONS 2012Cold compress
    "Local dry cold compresses"Non vesicant
    Figure 1, p. vii170
Brand names (ANVISA, Brazil) · DCB (Brazil)

DCB (Brazil)bortezomibe (nº 1335)

Brand names (ANVISA, Brazil)BORMHY, BORMIB, BORTECIP, BORTYZ, BORTYZ RTU, BOZEMYB, BOZORED, ELOME, MIBO, MIELOCADE, TOVAR, VELCADE, VELZARA, VERAZO, ZOMI, ZOMYLE

General recommendations of the guidelines

  • ONS/ASCO 2025Recommendation 1 · Strong; very low

    Use antidotes, when one exists, for vesicants and irritants with vesicant properties, rather than no antidote.

    Table 3, p. 388
  • ONS/ASCO 2025Recommendation 3 · Conditional; very low

    Thermal compress (cold or warm depending on the agent) rather than no compress.

    Table 3, p. 388
  • ONS/ASCO 2025Recommendation 4 · Conditional; very low

    Compress for more than 24 hours rather than 24 hours or less.

    Table 3, p. 388
  • ONS/ASCO 2025Recommendation 5 · Conditional; very low

    Central line extravasation: surgical referral or escalation of care in addition to conservative management.

    Table 3, p. 388
  • JSCN/JSMO/JASPO 2024CQ10a · Recommend (weak)

    Cold compression (weak recommendation).

    Table 1, CQ10a
  • JSCN/JSMO/JASPO 2024CQ10b · Not recommend (weak); D

    Non-use of warm compresses (weak recommendation).

    Table 1, CQ10b

Nonvesicant antineoplastic drugs

AfliberceptArsenic trioxideAsparaginaseBleomycinBrentuximab vedotinCarfilzomibCladribineClofarabineCyclophosphamideCytarabineEribulinEtoposide phosphateFludarabineGemcitabineInotuzumab ozogamicinInterferonsInterleukin-2MethotrexateMonoclonal antibodiesNelarabinePemetrexedPentostatinRaltitrexedTemsirolimus

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