Extravasation GuideTissue injury risk of antineoplastic extravasation

Paclitaxel (albumin-bound)

Paclitaxel ligado à albuminaPaclitaxel unido a albúmina

Risk class

  • Irritant with vesicant properties

If it extravasates

None of the guidelines names a specific antidote or compress for this drug. See the general recommendations.

References

Risk class: Irritant with vesicant propertiesONS/ASCO 2025 (Table 1, p. 385)

Not classified in: ESMO-EONS 2012, JSCN/JSMO/JASPO 2024

Details by guideline

Risk class in extravasation

  • ONS/ASCO 2025Irritant with vesicant properties
    Antimicrotubule agents, taxanes
    Table 1, p. 385

Not classified in: ESMO-EONS 2012, JSCN/JSMO/JASPO 2024

Brand names (ANVISA, Brazil) · DCB (Brazil)

DCB (Brazil)paclitaxel (nº 6786)

Brand names (ANVISA, Brazil)ABRAXANE

General recommendations of the guidelines

  • ONS/ASCO 2025Recommendation 1 · Strong; very low

    Use antidotes, when one exists, for vesicants and irritants with vesicant properties, rather than no antidote.

    Table 3, p. 388
  • ONS/ASCO 2025Recommendation 3 · Conditional; very low

    Thermal compress (cold or warm depending on the agent) rather than no compress.

    Table 3, p. 388
  • ONS/ASCO 2025Recommendation 4 · Conditional; very low

    Compress for more than 24 hours rather than 24 hours or less.

    Table 3, p. 388
  • ONS/ASCO 2025Recommendation 5 · Conditional; very low

    Central line extravasation: surgical referral or escalation of care in addition to conservative management.

    Table 3, p. 388
  • JSCN/JSMO/JASPO 2024CQ10a · Recommend (weak)

    Cold compression (weak recommendation).

    Table 1, CQ10a
  • JSCN/JSMO/JASPO 2024CQ10b · Not recommend (weak); D

    Non-use of warm compresses (weak recommendation).

    Table 1, CQ10b

Irritants with vesicant properties

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